|
| all news articles | by topics |
|
news
articles about singapore's wild places
|
| Eurekalert
12 Oct 05 Seaweed yields new compounds with pharmaceutical potential Contact: Jane M. Sanders jane.sanders@edi.gatech.edu Georgia Institute of Technology Research News Full report Extracts Researchers have discovered 10 new molecular structures with pharmaceutical potential in a species of red seaweed that lives in the shallow coral reef along the coastline of Fiji in the south Pacific Ocean. Some of these natural compounds showed the potential to kill cancer cells, bacteria and the HIV virus, according to research at the Georgia Institute of Technology. In fact, two of them exhibit anti-bacterial activity towards antibiotic-resistant Staphylococcus aureus at concentrations worth pursuing, though researchers don't know yet whether the concentrations of the compounds required to kill the bacterium would be harmful to humans. The compound that was isolated in the greatest abundance -- named bromophycolide A by the researchers -- killed human tumor cells by inducing programmed cell death (called apoptosis), a mechanism that is promising for development of new anti-cancer drugs, researchers noted. "We're only at the test-tube level so far," explained Julia Kubanek, a Georgia Tech assistant professor of biology, chemistry and biochemistry, who is the lead author on the paper. "The next step is to discover how these compounds work and then to study them in a more complex model system." The source of these new molecular structures is a red seaweed (Callophycus serratus) collected from four Fijian sites. Among the sites, researchers found variations in the molecular structures produced by the species. "There are chemical differences among populations of this seaweed species, even though two of the sites where it was collected are only about 2 kilometers apart," Kubanek noted. "… This shows us there are small, but valuable differences within species, and this genetic biodiversity is important to protect as a resource for the future." Researchers have been analyzing extracts from about 200 marine plant and invertebrate animal samples they collected from the Fijian coral reef in June 2004 with the permission of the Fijian government and local resource owners. "Marine organisms make molecules for their own purposes that we might co-opt for our own use as pharmaceutical agents," Kubanek explained. "The organisms' purposes include defense against predators, the ability to fight diseases, and the production of chemical cues, such as those used for sex recognition." Hay, Kubanek, and their colleagues collected baseball-sized samples of reef species that exhibit unusual growth and/or behavioral phenomena. Among their collection were soft corals, marine sponges, slugs, and green, red and brown seaweeds. Much research is left to do before any of these compounds are used to formulate a drug available on the market, Kubanek said. It typically takes at least a decade from the discovery of a compound to the marketing of a new drug. If that does happen in this case, Fijian villagers and the Fijian government would benefit financially from the discovery because of an agreement that is already in place, she added. Because of the long timeframe in getting a drug to market, the project in Fiji provides other immediate conservation and economic development benefits to villagers and the government. links Related articles on Wild Shores of Singapore |
| News articles are reproduced for non-profit educational purposes. | |
website©ria tan 2003 www.wildsingapore.com |